CIR-DDG: backbone-agnostic residual correction of antibody-antigen affinity changes with explicit cross-chain geometrytranslating…

arXiv:2608.27530v1 Announce Type: new Abstract: Motivation: Accurate prediction of mutation-induced protein--protein binding free-energy changes is important for antibody affinity maturation, yet scarce labels and complex interface geometry limit generalization. Heterogeneous…